studied as a novel, once-daily oral anti-cancer agent, including in a phase-3 randomized trial in patients (pts) with metastatic prostate cancer

As a single agent, tasquinimod demonstrated strong antitumor activity in Phase II clinical trials; however, it must be noted that 39% of patients still did not respond to therapy.45 These clinical findings are likely to reflect the fact that prostate cancer is a highly heterogeneous disease, and similar patterns of nonresponders are also seen in other therapies in advanced prostate cancer

2017-05-31 Data presented from phase II trials at the ESMO 2012 Congress show that two new agents, ODM-201 and tasquinimod, are active in prostate cancer. Data from two trials presented at the European Society for Medical Oncology (ESMO) 2012 Congress show that two new agents, ODM-201 and tasquinimod, are active in prostate cancer. Tasquinimod is an oral antiangiogenic agent, which has the potential for castration-resistant prostate cancer treatment. Tasquinimod binds to the regulatory Zn 2+ binding domain of HDAC4 with K d of 10-30 nM.

Tasquinimod prostate cancer

Aprea. Oncology Tasquinimod. Prostate cancer. Oncology.

Castration resistant prostate cancer remains a major clinical burden and novel therapeutic options are urgently required to improve survival. Tasquinimod is an orally administered quinoline-3-carboxamide with potent antiangiogenic and antitumorigenic action that has shown promise in the treatment of advanced prostate cancers.

leder till onödiga prostata- biopsier samt överdiagnos av lågriskcancer antiandrogens in men with prostate cancer in Sweden. Tasquinimod 7. Aflibercept. Defining the importanceof antioxidants for lung cancer progression.

Development of a new prostate cancer cell line and in vivo models and imaging methods for metastatic models of prostate cancer. I was also involved in a

Thus, the primary objective of this study is to determine the recommended dose of tasquinimod in combination with cabazitaxel and prednisone based on safety and tolerability in men with chemorefractory metastatic castration-resistant prostate cancer (CRPC).

Open-label, clinical phase I studies of tasquinimod in patients with castration-resistant prostate cancer. 1 Please help EMBL-EBI keep the data flowing to the scientific community! Thus, the primary objective of this study is to determine the recommended dose of tasquinimod in combination with cabazitaxel and prednisone based on safety and tolerability in men with chemorefractory metastatic castration-resistant prostate cancer (CRPC). Condition or disease.
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Tasquinimod has antiangiogenic, immunomodulatory, and antimetastatic properties, but it is also associated with toxicities, including skeletal pain, digestive disorders, fatigue, insomnia, and mental Tasquinimod (ABR‐215050) is an orally active quinoline‐3‐carboxamide analog that inhibits occurrence of experimental metastasis and delays disease progression of castration resistant prostate cancer in humans. Its mechanism of action is not fully elucidated, but previous studies show immunomodulatory and anti‐angiogenic effects. 2015-09-16 · One compound under active phase III investigation in prostate cancer, with a novel mechanism of action, is tasquinimod [Isaacs et al. 2006].

Projektet med tasquinimod är i en registreringsgrundande klinisk fas III- prostatacancer (metastatic Castrate Resistant Prostate Cancer (”mCRPC”)).
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2013-10-11

Tasquinimod binds to the regulatory Zn 2+ binding domain of HDAC4 with K d of 10-30 nM. Tasquinimod also is a S100A9 inhibitor. GlobalData has released its new PharmaPoint Drug Evaluation report, “Tasquinimod (Prostate Cancer) – Forecast and Market Analysis to 2022”. in prostate cancer and as a single agent in other solid tumors.

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inkluderande prostate cancer( Bjork et al, 2009; Pili et al, 2011; Armstrong et al, [] 2016; Fizazi et al, 2017), lever-, äggstocks-, njur- och magsäcks-cancer

Tasquinimod has been mostly studied in prostate cancer, but its mechanism of action suggests that it could be used to treat other cancers. Tasquinimod has previously been in development for the treatment of prostate cancer with completed phase I – III clinical trials.